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Lentigo maligna (LM) is a subtype of pre-invasive melanoma associated with chronic exposure to ultraviolet radiation, primarily affecting the head and neck. In situ [3,4] but is less frequently used in gynecologic cases. Surgical excision is the treatment of choice for LM.. The data on adjuvant therapy for vulvar …. In the literature there are only two case reports which describe the successful treatment of recurrent vaginal melanoma. 9 months 1 North Valley Dermatology Center, Chico, CA 95926, USA. However, this can be a surgical challenge for size, multifocal presentation with proximity to urethra or anus and tendency for local recurrence. The authors have indicated no significant interest with commercial supporters The primary treatment of both in situ and invasive vulvar melanoma is wide local excision of the primary neoplasm. Wide local excision of melanoma in-situ traditionally involves 5mm to 10mm margins. The novel topical immune response modifier imiquimod (Aldara; 3M Pharmaceuticals, St Paul, Minn) was used as a 5% cream, 3 times per week on Monday, Wednesday, and Friday in the evening and washed off in the morning. Epstein E Extensive lentigo maligna clearing with topical imiquimod Arch Dermatol 2003;139944- 945 PubMed Google Scholar Crossref. Melanoma in situ (MIS) is the earliest stage of malignant melanoma. Alternative topical therapy with imiquimod has been proposed in recent studies as a possible treatment for MIS. Imiquimod (Aldara ®) cream has shown to be effective in non-gynecologic cases of melanoma. Methods: Twelve patients with periocular melanoma in situ were treated with topical 5% imiquimod cream daily for a mean treatment get sustiva period of 3. This study aimed to evaluate the use of topical 5% imiquimod as an alternative approach for the treatment of residual melanoma in situ after surgical resection of the primary lesion Aldara is used for several skin conditions. Com PMID: 17966182 Abstract Lentigo maligna (LM) is an in situ melanoma that occurs in sun-damaged skin on the head and neck of elderly patients. Aldara should be applied just before bedtime and left on the skin for 6-10 hours. Over the past two decades, the incidence of MIS has increased. The excised tissue is sent to a dermatopathologist to ensure clear margins in situ. The cream was applied to the papules and nodules of metastatic melanoma with a 1-cm surrounding margin Topical 5% imiquimod cream was used as a primary treatment (n=6) or as an adjunctive therapy following local excision (n=2), cryotherapy (n=2), or excisional biopsy with cryotherapy (n=2). It accounts for 79% to 83% of all MIS tumours 1 North Valley Dermatology Center, Chico, CA 95926, USA. Traditional management options for melanoma in-situ include surgical excision, topical treatment with imiquimod (Aldara), or even superficial radiation therapy (SRT). Your doctor will tell you where to apply Aldara cream, and how often and for how long to apply it for your condition. 9 months Department of Dermatology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany. If your skin condition reappears you need to talk to your doctor. Squamous cell carcinoma in situ disappeared completely in 73% of the patients treated with Aldara. Treatment was given daily for 16 weeks. None of the patients in the placebo group experienced complete disappearance of squamous cell carcinoma in situ. Topical 5% imiquimod cream was used as a primary treatment (n=6) or as an adjunctive therapy following local excision (n=2), cryotherapy (n=2), or excisional biopsy with cryotherapy (n=2).
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